Senior Medicinal Chemist at TM3 Therapeutics B.V.

Candidate profile Senior Medicinal Chemist:

Experienced medicinal chemist with a track record in small molecule pharmaceutical development, ideally demonstrated in delivering molecules to clinic.

Awareness of the full process of drug development with consideration of activity, physicochemical properties, safety, and innovative modes of delivery. Skilled at rationalizing complex network SAR relationships, and propose creative solutions to desirable pharmacological properties, with efficient information feedback from assessment into further design. Demonstrated awareness of patent considerations, ideally through inventorship. Ability to clearly communicate in English, both orally and in documentation, across multiple levels including chemists and non-specialist scientists. Minimum PhD in chemistry-related scientific discipline or equivalent professional training, preferably with pharmaceutical industry experience including lead identification and optimization.


Lead medicinal chemistry programs generating novel chemical matter.

Co-ordination of early discovery and back-up chemistry, in conjunction with DMPK and pharmacology, for efficient compound evaluation.

Interpret and prioritize compound assessment data, with autonomy to make fundamental strategic decisions in company pipeline.

Responsibility for internal communication of target molecule design strategy.

About TM3 Therapeutics:

TM3 Therapeutics is an ambitious, exciting and science-driven biopharmaceutical company based in Leiden Bioscience park (NL), developing effective treatments for Inborn Errors in Metabolism, a group of rare but severe metabolic and often neurological disorders that primarily affect children. TM3 Therapeutics is working together with leading academic researchers, patients’ families and the medical professionals, committed to bringing innovative therapies to patients.

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