Scientist PDMS API Large Molecules at Janssen Vaccines

Department:

The department leads in the application of broad technical expertise, including new and innovative technologies, to support both marketed and clinical products. Participates in high caliber multi-functional teams to drive solutions to commercial manufacturing problems and to drive process improvement, technology transfer, and support process validation. Performs high level research and development activities supporting high value commercial products. Performs technology transfer for new products and manufactures tox and phase 1/2a clinical material. Projects will often be high priority with high level interest and attention.

Responsibilities & Accountabilities: 

This position will play a lead role in support of high value commercial products manufactured within plants in Leiden, Ireland and the United States, helping to ensure uninterrupted supply of product to the market. This position will serve as a technical and scientific resource for large scale perfusion and fed batch bioreactor operations and for large scale downstream purification processes. A solid theoretical foundation and practical experience in bioreactor process technology and antibody purification will be brought into practice for development and introduction of new tox and phase1/2a clinical products (e.g. large proteins, mAbs, bispecific duobodies). This position may take on responsibility for specific products and as such may be responsible to lead site product teams or act as scientific or technical lead during technology transfers of new products.

Qualifications, Education, Skills & Experience:     

  • PhD degree with at least 3 years of experience in Biotechnology, Bioprocess Engineering, Biochemistry, Biochemical engineering

  • Strong technical orientation with up to date knowledge on bioreactor process technology and downstream purification of large molecules (protein / mAb / duobodies) for R&D purposes (GLP toxicology & GMP clinical)

  • Familiarity with Process Excellence and Six Sigma techniques is a plus.

  • Experience with statistical software packages (e.g. Minitab) and Multivariate analysis is a plus

  • Experience with Process validation, Process improvements and Commercial manufacturing support.

  • Personal characteristics: Highly results driven, with focus on customer satisfaction and on-time completion of projects.

  • Excellent interpersonal and collaborative skills, both oral and written, fluent in both Dutch and English, to support working in an international environment with frequent contact in the United States, Ireland and Belgium as well as in Leiden.

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