PhD student - PersonalizeAF at Ncardia

Are you a talented and motivated early-stage researcher looking for a PhD program in an industry setting?

 

We're searching for a researcher to advance an exciting project: 'Protocol standardization for iPSC-derived in vitro models of atrial fibrillation'. This project is part of the PersonalizeAF PhD program - a European Training Network for Atrial Fibrillation.

Project description

The development of effective research models of chronic AF is one of the main barriers to elucidating the underlying mechanisms of this arrhythmia and enabling design of effective therapies. In this project, you will:

  • Develop robust and scalable protocols for generation of atrial-like cardiomyocytes (hiPSC-aCMs) and perform extensive characterization / functional assessment of these cells
  • Utilize hiPSC-aCMs to generate in vitro AF models with different stages of remodeling, and evaluate the relation between gene expression / protein changes and functional readouts (e.g. electrophysiological modifications), as well as to screen for compounds that might reverse the disease phenotype.

Primary tasks and responsibilities

  • Perform independent scientific research within a collaborative international research/training consortium
  • Deliver written reports of your research on a regular basis
  • Prepare a doctoral thesis on the topic of atrial fibrillation
  • Publish scientific articles related to the research project of the assignment
  • Support the valorization of research results into tangible deliverables
  • Participate to scientific meetings and conferences to present your research to the scientific community
  • Actively participate in outreach activities aimed to promote your scientific research to a wider audience
  • Maintain contact with consortium members and benefit from the tailored training program

Take part in planned secondments: 1) Universitaets-Klinikum Freiburg (M15-18): patch-clamp of hiPSC-aCM, 2) Fundación para la investigación Biomédica del Hospital Gregorio Marañón (M23-25): optical and voltage mapping of hiPSC-aCM and comparison with clinical phenotypes of remodelling.

Job location: Ncardia Leiden, the Netherlands

Position Type: Full-Time

Interested? Read more about the position here.

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