A joint effort between Leiden University’s Professor Ubbink’s lab and ZoBio’s Assay Development and Screening team has advanced fragment-based drug discovery targeting membrane proteins. Supported by a Dutch Research Council (NWO) AES grant, the project utilized protein-lipid nanodiscs to study how lipid composition affects small molecule interactions with the membrane enzyme CYP3A4.
Findings revealed that lipid types significantly influence off-target binding, underscoring the importance of lipid selection in drug screening. This research, published in Chemical Biology and Drug Design, offers valuable insights for developing therapeutics targeting complex membrane proteins
Read more here
VarmX, a biotechnology company based at the Leiden Bio Science Park (LBSP), has entered into a strategic collaboration and option agreement with global biotechnology leader CSL...
Leiden University Medical Center (LUMC), via its Cairelab initiative, together with the Dutch Police, have been declared winners of the National AI Challenge 2025, organized by...
Marieke Vinkenoog and Simon Christian Hansmann have been awarded the Krijn Rietveld Memorial Innovation Awards for their research in blood donation and colorectal cancer. Vinkenoog’s work on predictive modeling for donor eligibility and Hansmann’s identification of cancer cells linked to tumor recurrence exemplify the integration of advanced scientific methods to address pressing health challenges.