A joint effort between Leiden University’s Professor Ubbink’s lab and ZoBio’s Assay Development and Screening team has advanced fragment-based drug discovery targeting membrane proteins. Supported by a Dutch Research Council (NWO) AES grant, the project utilized protein-lipid nanodiscs to study how lipid composition affects small molecule interactions with the membrane enzyme CYP3A4.
Findings revealed that lipid types significantly influence off-target binding, underscoring the importance of lipid selection in drug screening. This research, published in Chemical Biology and Drug Design, offers valuable insights for developing therapeutics targeting complex membrane proteins
Read more here
The Court of Audit visited LBSP to explore how science and entrepreneurship create public value, with stops at TNO, Peregrion, NTrans, and VarmX sparking discussion on biotech innovation.
Thank you to everyone who joined us last Thursday at Grand Café de Stal. The room was full of energy, curiosity, and conversation as we explored the next wave of biotech...
At BIO International Convention in Boston, biotech ambition turns into partnership and progress. This year, Leiden Bio Science Park joined the Dutch delegation at the Netherlands...