Comet Therapeutics B.V.

Comet is building the world’s premier coenzyme engineering platform addressing unmet medical needs from inborn errors of metabolism to fatty liver, neurological diseases and beyond. CoEnzyme A (CoA) is essential to numerous cellular processes including the metabolism of fatty acids, amino acids and sugars; the regulation of gene expression; and mitochondrial health and the proper functioning of the TCA cycle — the source of energy all cells need to live. Depletion of particular CoA molecules plays a role in many rare, genetic disorders of metabolism. Dysregulated CoA metabolism is also a key factor in conditions with neurometabolic and immunometabolic origins. Comet Therapeutics addresses these profound unmet medical needs with its CoEnzyme Metabolism (CoMET™) Platform.